Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter. 2010 5(1):99–118.Ĭordero JB, Macagno JP, Stefanatos RK, Strathdee KE, Cagan RL, Vidal M. The senescence-associated secretory phenotype: the dark side of tumor suppression. A tumor suppressive activity of Drosophila Polycomb genes mediated by JAK/STAT signaling. Disruption of lysosome function promotes tumor growth and metastasis in Drosophila.
Oncogenic Ras stimulates Eiger/TNF exocytosis to promote growth.
Mutation selection and the natural history of cancer. Scribble mutants cooperate with oncogenic Ras or notch to cause neoplastic overgrowth in Drosophila. Why don’t we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Functional exploration of colorectal cancer genomes using Drosophila. Keywordsīangi E, Murgia C, Teague AGS, Sansom OJ, Cagan RL. Recent approaches toward identification of novel therapeutics using fly cancer models have further proved Drosophila as a robust system with great potentials for cancer research as well as anti-cancer therapy. The mosaic technique has also led to the discovery of important tumor-suppressor pathways such as the Hippo pathway and the elucidation of the mechanisms underlying tumor growth and metastasis via regulation of cell polarity, cell-cell cooperation, and cell competition. Particularly, the development of genetic mosaic technique in Drosophila has enabled us to recapitulate basic aspects of human cancers, including clonal evolution, tumor microenvironment, cancer cachexia, and anticancer drug resistance. Over the last few decades, Drosophila cancer models have made great contributions to our understanding toward fundamental cancer processes.
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